ID   HRCA_MYCA1              Reviewed;         343 AA.
AC   A0QEA3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=MAV_2022;
OS   Mycobacterium avium (strain 104).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=243243;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=104;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000479; ABK65746.1; -; Genomic_DNA.
DR   RefSeq; WP_011724542.1; NC_008595.1.
DR   AlphaFoldDB; A0QEA3; -.
DR   SMR; A0QEA3; -.
DR   EnsemblBacteria; ABK65746; ABK65746; MAV_2022.
DR   KEGG; mav:MAV_2022; -.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001574; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..343
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010423"
SQ   SEQUENCE   343 AA;  36872 MW;  DDEB62D252624066 CRC64;
     MGSADERRFE VLRAIVADFI ATKEPIGSKT LVERHNLGVS SATVRNDMAV LEAEGYITQP
     HTSSGRVPTE KGYREFVDRL DDVKPLSAAE RRAIQNFLES GVDLDDVLRR AVRLLAQLTR
     QVAIVQYPTL SSSTVRHLEV IALTPARLLM VVITDSGRVD QRIVELGDVI DDHELSRLRE
     MLGQALVGKK LSAASVAVAD LAEQLRSPDG LGDAVGRSAT VLLESLVEHS EERLLMGGTA
     NLTRNAADFG GSLRSILEAL EEQVVVLRLL AAQQEAGKVT VRIGYETAAE QMVGTSMVTT
     AYGTSDTVYG GMGVLGPTRM DYPGTIASVA AVAMYIGEVL GAR