HRCA_MYCCT
ID HRCA_MYCCT Reviewed; 340 AA.
AC P71498; Q2SSB2;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 2.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=MCAP_0367;
OS Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343
OS / NCTC 10154).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=340047;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8995799; DOI=10.1099/00207713-47-1-38;
RA Falah M., Gupta R.S.;
RT "Phylogenetic analysis of mycoplasmas based on Hsp70 sequences: cloning of
RT the dnaK (hsp70) gene region of Mycoplasma capricolum.";
RL Int. J. Syst. Bacteriol. 47:38-45(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=California kid / ATCC 27343 / NCTC 10154;
RA Glass J.I., Lartigue C., Pfannkoch C., Baden-Tillson H., Smith H.O.,
RA Venter J.C., Roske K., Wise K.S., Calcutt M.J., Nelson W.C., Nierman W.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; U51235; AAB09428.1; -; Genomic_DNA.
DR EMBL; CP000123; ABC01793.1; -; Genomic_DNA.
DR RefSeq; WP_011387252.1; NC_007633.1.
DR AlphaFoldDB; P71498; -.
DR SMR; P71498; -.
DR EnsemblBacteria; ABC01793; ABC01793; MCAP_0367.
DR GeneID; 23778677; -.
DR KEGG; mcp:MCAP_0367; -.
DR HOGENOM; CLU_050019_1_0_14; -.
DR OMA; DYPGTMG; -.
DR OrthoDB; 1510750at2; -.
DR PhylomeDB; P71498; -.
DR Proteomes; UP000001928; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.390.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 3: Inferred from homology;
KW Repressor; Stress response; Transcription; Transcription regulation.
FT CHAIN 1..340
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_0000182501"
FT CONFLICT 128..129
FT /note="KQ -> SK (in Ref. 1; AAB09428)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="Missing (in Ref. 1; AAB09428)"
FT /evidence="ECO:0000305"
FT CONFLICT 319..340
FT /note="VDYNQVNQLMNLIIEIINAKEN -> GRLQPSKPVNELNYWNY (in Ref.
FT 1; AAB09428)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 340 AA; 39317 MW; 06DF669A0A31FCDB CRC64;
MLTKRQVKIL QTIVEEFIKT NQPVGSKRIL ELLDIKISSA TIRNESAILE HEGYLEKQHT
SSGRTPSTKG YRYYVDNIMK LDSADYTRLK IYLNQLLDLR KYDIDKTINY ASEIISELTK
MTAVVIKKQN IKNIKLKKIE LILLSEFLAS VLFIFSDGDV QNKMFNLKDI SLSDLKIAIK
LFSDFLVDVK LDEIDQYLND LKHQLSLSIK QYDYVLNTFI NTILESKNEQ KETHGMRYML
ENPEFNDTNK LKNAVKLVEQ LSPFDWFNIA YESNKNMNKI AIKIGNEIDQ INDDISMIAT
ELKIGNSSTV LTLVGPKRVD YNQVNQLMNL IIEIINAKEN
