ID   HRCA_MYCGA              Reviewed;         349 AA.
AC   Q7NBC5;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=MYCGA3540;
GN   ORFNames=MGA_1270;
OS   Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
OS   (Mycoplasmoides gallisepticum).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=710127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R(low / passage 15 / clone 2);
RX   PubMed=12949158; DOI=10.1099/mic.0.26427-0;
RA   Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F.,
RA   Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.;
RT   "The complete genome sequence of the avian pathogen Mycoplasma
RT   gallisepticum strain R(low).";
RL   Microbiology 149:2307-2316(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP56704.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE015450; AAP56704.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011884393.1; NC_004829.2.
DR   AlphaFoldDB; Q7NBC5; -.
DR   SMR; Q7NBC5; -.
DR   GeneID; 57203653; -.
DR   KEGG; mga:MGA_1270; -.
DR   HOGENOM; CLU_050019_1_0_14; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001418; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..349
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182502"
SQ   SEQUENCE   349 AA;  40190 MW;  873B460D133EB0CC CRC64;
     MNNKLTERQI LILKAIINEY ISTATAVGSK IILEKYFNNE VSSATIRNEM SVLEKEKYIE
     KPHTSAGRIP TIKGYQYYEA NLAETKISER LKQKLMAILN KRYHSIDEVI EQSVEFINNV
     TNLPSVITKF KSYDLLKRMD LIKINNNTAI ILIVSSSGEV IKKTIKYQNS IQYNDVSTCV
     QIFNDRLVDT PFIELKEKLT AIKEIVRTKV HEYEFVMQRI VNYIFDINEK STINIKGTKK
     LVIHPEFHDH NKLSEILNLL ENTSIWEQIS FMQQKTGKSV ITFGQDIGIE GISVASTLIE
     TEQNKHQIAI VGPNRMEYGK IKGLLNILKE QVEKIDHLNL PLEEINKES