HRCA_MYCLE
ID HRCA_MYCLE Reviewed; 343 AA.
AC Q9CCN2; Q49749; Q49772;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=ML0624;
GN ORFNames=B1937_F1_18/B1937_F3_95;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Smith D.R., Robison K.;
RL Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA17179.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U00016; AAA17153.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00016; AAA17179.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AL583919; CAC30132.1; -; Genomic_DNA.
DR PIR; H86986; H86986.
DR PIR; S72585; S72585.
DR PIR; S72611; S72611.
DR RefSeq; NP_301517.1; NC_002677.1.
DR RefSeq; WP_010907841.1; NC_002677.1.
DR AlphaFoldDB; Q9CCN2; -.
DR SMR; Q9CCN2; -.
DR STRING; 272631.ML0624; -.
DR EnsemblBacteria; CAC30132; CAC30132; CAC30132.
DR KEGG; mle:ML0624; -.
DR PATRIC; fig|272631.5.peg.1105; -.
DR Leproma; ML0624; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_2_0_11; -.
DR OMA; DYPGTMG; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.390.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repressor; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..343
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_0000182505"
SQ SEQUENCE 343 AA; 36648 MW; ACA38493F9BC7A87 CRC64;
MGNADERRFE VLRAIVADFV ATKEPIGSRA LVERHNLGVS SATIRNDMAV LEAEGYITQP
HTSSGRVPTE KGYREFVDRL EDVKPLSAAE RRAIQSFLES GVDLDDVLRR AVRLLAQLTC
QVAVVQYPTL STSTVRHLEV IALSPARLLM VVITESGRVD QRIAELGDVI DDYQLSQLRE
MLSQAMGGKK LSAASAAVAD LVGRFRGTGG LANAVGRSAN VLLESLVEHT EERLLLGGTA
NLTRNSADFG GSLRSILEAL EEQVVVLRLL AAQQEAGKVT VRIGHETAAE QIMGTSMVST
AYGTSGTVYG GMGVLGPTRM DYPGTIASVA AVALYIGEVL GAR
