ID   HRCA_MYCMS              Reviewed;         340 AA.
AC   Q6MT04;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=MSC_0612;
OS   Mycoplasma mycoides subsp. mycoides SC (strain PG1).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG1;
RX   PubMed=14762060; DOI=10.1101/gr.1673304;
RA   Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
RA   Johansson K.-E., Pettersson B., Uhlen M.;
RT   "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain
RT   PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP).";
RL   Genome Res. 14:221-227(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BX293980; CAE77234.1; -; Genomic_DNA.
DR   RefSeq; NP_975592.1; NC_005364.2.
DR   AlphaFoldDB; Q6MT04; -.
DR   SMR; Q6MT04; -.
DR   STRING; 272632.MSC_0612; -.
DR   EnsemblBacteria; CAE77234; CAE77234; MSC_0612.
DR   KEGG; mmy:MSC_0612; -.
DR   PATRIC; fig|272632.4.peg.659; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_14; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001016; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..340
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182507"
SQ   SEQUENCE   340 AA;  39335 MW;  9127DD250FC352F7 CRC64;
     MLTNRQIKIL QTIVEEFIKT NQPVGSKRIL ELLNMKISSA TIRNESATLE HEGYLEKQHT
     SSGRTPSTKG YRYYVDNIMK LDSADYTRLK IYLNQLLDLR KYDIDKTINY ASEIISELTK
     MTAVVIKKQN IKDIKLKKIE LILLSEFLAS VLFIFSDGDV QNKMFNLKDV ALSDLKIAIK
     LFSDVLVDVK LDEIDQYLND LKHQLFLSIK QYDYVLNTFI NTILESKNEQ KETHGMRYML
     ENPEFNDTNK LKNAVKLVEQ LSPFDWFNIA YESNKNMNKI AIKIGNEIDQ INDDISMIAT
     ELKIGNSSTV LTLVGPKRVD YNQVNQLMNL IIEIINTKEN