ID   HRCA_MYCPN              Reviewed;         351 AA.
AC   P75351;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=MPN_124;
GN   ORFNames=MP030;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; U00089; AAB95678.1; -; Genomic_DNA.
DR   PIR; S73356; S73356.
DR   RefSeq; NP_109812.1; NC_000912.1.
DR   RefSeq; WP_010874481.1; NC_000912.1.
DR   AlphaFoldDB; P75351; -.
DR   SMR; P75351; -.
DR   IntAct; P75351; 1.
DR   STRING; 272634.MPN_124; -.
DR   EnsemblBacteria; AAB95678; AAB95678; MPN_124.
DR   GeneID; 66609226; -.
DR   KEGG; mpn:MPN_124; -.
DR   PATRIC; fig|272634.6.peg.131; -.
DR   HOGENOM; CLU_050019_1_0_14; -.
DR   OMA; DYPGTMG; -.
DR   BioCyc; MPNE272634:G1GJ3-205-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..351
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182510"
SQ   SEQUENCE   351 AA;  40462 MW;  96E27CA5924E76E7 CRC64;
     MKNLTTRQAQ ILKAIINEYI AYPVPVGSKL LTKKYFKNLS GGTLRNEMAV LEKEGYLKKN
     HISSGRIPSQ LGYQYYVKLL TKNDDKSNLK TRLRAIILQK HKTIDEIIEL GVKFINEMVN
     LPVVLTHFSS DEVLKKIDLI MLDQSCALLL LVSASGNVFK KTISYANQRQ FEDIMVCVRI
     FNDRIIDTRF CDIAQHLDVL KEIIRSKVHE YQYVIDEILF KLFNFEEFQQ ARKQVYGIHY
     LAQQPEFANQ ERLTRILNLL EDTSVWQQMA FMNQNNQTTN ITFGDKLGLE GEEVSVASTL
     INTTNESKHQ LAIVGPTRMD YQKVKALLLT LKEEIEEYDK QLHGGKTTSS T