ID   HRCA_MYCPU              Reviewed;         347 AA.
AC   Q98R68;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=MYPU_1420;
OS   Mycoplasmopsis pulmonis (strain UAB CTIP) (Mycoplasma pulmonis).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasmopsis.
OX   NCBI_TaxID=272635;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAB CTIP;
RX   PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA   Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA   Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.;
RT   "The complete genome sequence of the murine respiratory pathogen Mycoplasma
RT   pulmonis.";
RL   Nucleic Acids Res. 29:2145-2153(2001).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AL445563; CAC13315.1; -; Genomic_DNA.
DR   PIR; F90529; F90529.
DR   RefSeq; WP_010924946.1; NC_002771.1.
DR   AlphaFoldDB; Q98R68; -.
DR   SMR; Q98R68; -.
DR   STRING; 272635.MYPU_1420; -.
DR   EnsemblBacteria; CAC13315; CAC13315; CAC13315.
DR   KEGG; mpu:MYPU_1420; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_14; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   BioCyc; MPUL272635:G1GT6-143-MON; -.
DR   Proteomes; UP000000528; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..347
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182511"
SQ   SEQUENCE   347 AA;  39856 MW;  D822D6BACD3783E0 CRC64;
     MNFENKEIKL ETKKTILFKN IVELYLRTGK PIGSKFLVEQ DYGLGKSSAT IRNMMHEFEE
     IGLLEKSHIS SGRIPSTLGL KYYVKYLANS EDSDLKKQLK KLFFQRKLTI DETIELAAKS
     ISEIVGLTMV TSTENSFETL KSIQLVLLDK NESIIIIVLS SGKVISKKLA MKDSIVLDDL
     RIAVRIFKER LIDTKVSELH EKTLALKPIL KISIQNYEDI LQEFIINIFD FEVSQTNNVY
     GKKNIILARD IKREDLTKII KLIESTSIWQ TIEDNLEEEE NIKIEIRPDN SSFLSKKISI
     DNKIREISVV GSKKMDYAKA KSALMLIEDL VEENKKKEKG NNEDNEE