ID   HRCA_MYCTA              Reviewed;         343 AA.
AC   A5U567;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=MRA_2397;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000611; ABQ74167.1; -; Genomic_DNA.
DR   RefSeq; WP_003412252.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U567; -.
DR   SMR; A5U567; -.
DR   STRING; 419947.MRA_2397; -.
DR   EnsemblBacteria; ABQ74167; ABQ74167; MRA_2397.
DR   GeneID; 45426359; -.
DR   KEGG; mra:MRA_2397; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..343
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010431"
SQ   SEQUENCE   343 AA;  36475 MW;  2FE6DC797F05BA0D CRC64;
     MGSADERRFE VLRAIVADFV ATQEPIGSKS LVERHNLGVS SATVRNDMAV LEAEGYITQP
     HTSSGRVPTE KGYREFVDRL EDVKPLSSAE RRAIQSFLES GVDLDDVLRR AVRLLAQLTR
     QVAVVQYPTL STSTVRHLEV IALTPARLLM VVITDSGRVD QRIVELGDVI DDHQLAQLRE
     ILGQALEGKK LSAASVAVAD LASQLGGAGG LGDAVGRAAT VLLESLVEHT EERLLLGGTA
     NLTRNAADFG GSLRSILEAL EEQVVVLRLL AAQQEAGKVT VRIGHETASE QMVGTSMVST
     AYGTAHTVYG GMGVVGPTRM DYPGTIASVA AVALYIGDVL GAR