ID   HRCA_NITWN              Reviewed;         362 AA.
AC   Q3SW79;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Nwi_0194;
OS   Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 /
OS   NCIMB 11846 / Nb-255).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Nitrobacter.
OX   NCBI_TaxID=323098;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255;
RX   PubMed=16517654; DOI=10.1128/aem.72.3.2050-2063.2006;
RA   Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L.,
RA   Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J.,
RA   Hickey W.J.;
RT   "Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium
RT   Nitrobacter winogradskyi Nb-255.";
RL   Appl. Environ. Microbiol. 72:2050-2063(2006).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000115; ABA03462.1; -; Genomic_DNA.
DR   RefSeq; WP_011313530.1; NC_007406.1.
DR   AlphaFoldDB; Q3SW79; -.
DR   SMR; Q3SW79; -.
DR   STRING; 323098.Nwi_0194; -.
DR   EnsemblBacteria; ABA03462; ABA03462; Nwi_0194.
DR   KEGG; nwi:Nwi_0194; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000002531; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..362
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010437"
SQ   SEQUENCE   362 AA;  39127 MW;  08C5070B23D8C9BE CRC64;
     MAHHDPIGLI APNAGLAQLN ERSRDIFRQI VESYLATGEP VGSRNISRLI AVPLSPASVR
     NVMSDLEQLG LIYAPHTSAG RLPTELGLRF FVDALMQVGD LTEPERQSIQ SQLASVGKAQ
     SVEAALEEAL TRLSGLTRTA AVVLTAKSNV RLKHIEFVRL EPDKALVVLV AEDGQVENRV
     LTLPSGVPAS ALTEASNFLN ARIRGRTLAE ARLELETALA QSKAELDQLT QKIVAAGIAS
     WSGGDSDDRQ LIVRGHANLL EDLHAMEDLE RVRLLFDDLE TKREVIDLLG RAERADGVRI
     FIGSENKLFS LSGSSTIIAP YSDGAGHIVG VLGVIGPTRL NYARVIPMVD YAARIVSQML
     GR