ID   HRCA_NODSP              Reviewed;         365 AA.
AC   Q84B70;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
OS   Nodularia spumigena.
OC   Bacteria; Cyanobacteria; Nostocales; Aphanizomenonaceae; Nodularia.
OX   NCBI_TaxID=70799;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NSOR10;
RX   PubMed=12664164; DOI=10.1007/s00239-002-2415-0;
RA   Moffitt M.C., Neilan B.A.;
RT   "Evolutionary affiliations within the superfamily of ketosynthases reflect
RT   complex pathway associations.";
RL   J. Mol. Evol. 56:446-457(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AY210783; AAO39777.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q84B70; -.
DR   SMR; Q84B70; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..365
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182515"
SQ   SEQUENCE   365 AA;  40732 MW;  73E1957C60E68721 CRC64;
     MEVQLTNRQQ HILWATVRHY IATAEPVGSK ALVDEYDLGV SSATIRNVMG VLEKSGLLYQ
     PHTSAGRIPS DSGYRIYVDQ LITPGLRDAA RTDVLAKEVE LALQNRLHWE DWSLEAVLQG
     AAQILATVSG CISLITMPQT TTAILRHLQL MQIEANKIML IVVTDDYETH SKLMNLSPTE
     EEAKLDADGI DHELKIVSNF LNTHLRGRSL LELATLDWSD LDQEFQRYGE FLKGSVTELT
     RRHLTPTTTQ IMVRGVAEVL RQPEFSQLQQ VQTIIQLLEE EQDQLWRLIF AEPETEEAGK
     SKVTVRIGTE NPLEPIRTCT LITSTYRRGL LPVGSVGVLG PTRLDYDSAI AVVAAAADYL
     SDAFS