ID   HRCA_NOSP7              Reviewed;         376 AA.
AC   B2J938;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Npun_F5754;
OS   Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=63737;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29133 / PCC 73102;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA   Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RT   "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001037; ACC84054.1; -; Genomic_DNA.
DR   RefSeq; WP_012411997.1; NC_010628.1.
DR   AlphaFoldDB; B2J938; -.
DR   SMR; B2J938; -.
DR   STRING; 63737.Npun_F5754; -.
DR   PRIDE; B2J938; -.
DR   EnsemblBacteria; ACC84054; ACC84054; Npun_F5754.
DR   KEGG; npu:Npun_F5754; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_3; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   PhylomeDB; B2J938; -.
DR   Proteomes; UP000001191; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..376
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092823"
SQ   SEQUENCE   376 AA;  42179 MW;  D8A9A82B366B93A1 CRC64;
     MEVQLTNRQQ HILWATVRHY IATAEPVGSK ALVEEYDLGV SSATIRNVMG VLEKSGLLYQ
     PHASAGRVPS DSGYRIYVDQ LITPSLRSRS VSQTDATRTE TLGREIEVAL QKHLQWEDRS
     LETLLQGAAQ ILATLSGCIS LITMPQTTTA LLRHLQLVQI EAGRIMLIVV TDGYETHSKL
     MDLSPIPEET QRDSEVIDRE LQIVSNFLNT HLRGRSLLEL ANLNWSELDQ EFQRYGEFLK
     NSVAELTRRT LAPTATQIMV RGVSEVLRQP EFSQLQQVQT IIHLLEEEQD QLWRLIFEEP
     EPEDIGKSRV TVRIGAENPL EPIRTCTLIS SNYRRGSIPV GSVGVLGPTR LDYESAIAVV
     ASAADYLSEA FSYFNP