ID   HRCA_NOSS1              Reviewed;         365 AA.
AC   Q8YPZ6;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=alr4044;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BA000019; BAB75743.1; -; Genomic_DNA.
DR   PIR; AE2311; AE2311.
DR   RefSeq; WP_010998184.1; NZ_RSCN01000023.1.
DR   AlphaFoldDB; Q8YPZ6; -.
DR   SMR; Q8YPZ6; -.
DR   STRING; 103690.17133179; -.
DR   EnsemblBacteria; BAB75743; BAB75743; BAB75743.
DR   KEGG; ana:alr4044; -.
DR   eggNOG; COG1420; Bacteria.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..365
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182439"
SQ   SEQUENCE   365 AA;  40740 MW;  13FD4DB1A80F46AA CRC64;
     MQVQLTNRQQ HILWATVRHY IATAEPVGSK ALVEEYDLGV SSATIRNVMG VLEKSGLLYQ
     PHTSAGRVPS DSGYRIYVDQ LITPSLRDTT RAEVLAKEVE SALQQHLQWE DWSLEILLQG
     AAQILASLSG CISLITMPQT NTASVRHLQL MQIETGRIML ILVTDSYETH SKLMDLPPAR
     SETKPDPEVI DRELQIVSNF LNSHLRGRSL LEISTLDWSQ LDREFQSYGE FLKNSVAELA
     HRSAAPAATQ IMVRGLAEVL RQPEFSQLQQ VKTIIQLLEE EQEQLWRLIF EEPELEDTHK
     SKVTVRIGAE NPLEPIRTCS LISSTYRRGG VPLGSVGVLG PTRLDYESAI AVVAAAADYL
     SEAFS