ID   HRCA_ONYPE              Reviewed;         342 AA.
AC   Q6YPL9;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=PAM_706;
OS   Onion yellows phytoplasma (strain OY-M).
OC   Bacteria; Tenericutes; Mollicutes; Acholeplasmatales; Acholeplasmataceae;
OC   Candidatus Phytoplasma; Candidatus Phytoplasma asteris.
OX   NCBI_TaxID=262768;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OY-M;
RX   PubMed=14661021; DOI=10.1038/ng1277;
RA   Oshima K., Kakizawa S., Nishigawa H., Jung H.-Y., Wei W., Suzuki S.,
RA   Arashida R., Nakata D., Miyata S., Ugaki M., Namba S.;
RT   "Reductive evolution suggested from the complete genome sequence of a
RT   plant-pathogenic phytoplasma.";
RL   Nat. Genet. 36:27-29(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AP006628; BAD04791.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6YPL9; -.
DR   SMR; Q6YPL9; -.
DR   STRING; 262768.PAM_706; -.
DR   EnsemblBacteria; BAD04791; BAD04791; PAM_706.
DR   KEGG; poy:PAM_706; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_14; -.
DR   OMA; DYPGTMG; -.
DR   BioCyc; OYEL262768:G1G26-859-MON; -.
DR   Proteomes; UP000002523; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..342
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182517"
SQ   SEQUENCE   342 AA;  39018 MW;  03AF9F7E93E306D1 CRC64;
     MMNMLSDRKK LILKAVVENY SQKGQPVGSK LLTHLPYLKF ASATIRYDMV QLEKEGFLQK
     NHTSSGRVPS FKGYTYYLNH LLTRDHDVAC MFESIDKVIQ KKRFCKGQVI KEALSLLNNL
     TNYTAMAIGS DIFNNSKINK IDFIPLNSTQ AVILIITDKG NVQHQNISLD QTKEISIYDL
     KDVVQVVNDL LTDKFLSEAA NIIQSDFFKQ TIAKYICFQE QLIALFMEVF SSFASENLYF
     SGVSKMLEKP ELSNPEIIKK FMGLLERKEL LKIMLNQDSL SFKFSDGLQL TPLKDCMILS
     IPFDVNPNEK GRIAVVGPSW MKYPKVIPIL EYLAVHLSKL ND