ID   HRCA_PARMW              Reviewed;         324 AA.
AC   Q7U3Z7;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=SYNW2279;
OS   Parasynechococcus marenigrum (strain WH8102).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Parasynechococcus; Parasynechococcus marenigrum.
OX   NCBI_TaxID=84588;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH8102;
RX   PubMed=12917641; DOI=10.1038/nature01943;
RA   Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P.,
RA   Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T.,
RA   Dufresne A., Partensky F., Webb E.A., Waterbury J.;
RT   "The genome of a motile marine Synechococcus.";
RL   Nature 424:1037-1042(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BX569695; CAE08794.1; -; Genomic_DNA.
DR   RefSeq; WP_011129132.1; NC_005070.1.
DR   AlphaFoldDB; Q7U3Z7; -.
DR   SMR; Q7U3Z7; -.
DR   STRING; 84588.SYNW2279; -.
DR   EnsemblBacteria; CAE08794; CAE08794; SYNW2279.
DR   KEGG; syw:SYNW2279; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_3; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001422; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..324
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182550"
SQ   SEQUENCE   324 AA;  35547 MW;  4A1E909B36EA6F3E CRC64;
     MKPLSARQQQ VLQATVHHYV DTMEPVGSRT LVQRFGIPAS SATVRSAMGA LEKRGLLTQP
     HTSAGRIPSA LGYRCYVDDL LPEPGVAVQH LERELTGLSL RWAALDDLLQ QLARRLTDFT
     GLMSLITRPQ QPRAQLEAIR LVQSGDRLLV MLVEDSGRAS HLNLRLPPGA SDELTAIERW
     TDQQLEDGSI NWRSLPPQLQ RSGDVLRSAL DHPSMSPETP LVVHGLSRLV AEPEFHSTAE
     LRPLLELIDD QPCAVVSATD QPGVWIGEEH PQKALQACSV VQAPYRCGQE GVGQVALVGP
     MRMAYATAHA AVQRVARHLD LLLN