ID   HRCA_PARPJ              Reviewed;         339 AA.
AC   B2SXB7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Bphyt_0732;
OS   Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)
OS   (Burkholderia phytofirmans).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=398527;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17436 / LMG 22146 / PsJN;
RX   PubMed=21551308; DOI=10.1128/jb.05055-11;
RA   Weilharter A., Mitter B., Shin M.V., Chain P.S., Nowak J., Sessitsch A.;
RT   "Complete genome sequence of the plant growth-promoting endophyte
RT   Burkholderia phytofirmans strain PsJN.";
RL   J. Bacteriol. 193:3383-3384(2011).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001052; ACD15156.1; -; Genomic_DNA.
DR   RefSeq; WP_012431792.1; NC_010681.1.
DR   AlphaFoldDB; B2SXB7; -.
DR   SMR; B2SXB7; -.
DR   STRING; 398527.Bphyt_0732; -.
DR   EnsemblBacteria; ACD15156; ACD15156; Bphyt_0732.
DR   KEGG; bpy:Bphyt_0732; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_4; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001739; Chromosome 1.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..339
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092800"
SQ   SEQUENCE   339 AA;  37123 MW;  27E0AAF1641C1587 CRC64;
     MLDPRAQTLL KTLIERYIAE GQPVGSRTLS RYSGLELSPA TIRNVMSDLE DLGLVISPHT
     SAGRIPTPRG YRLFVDTMLT VESAADEEAV TRTVKTTLQA GEPQKIVAAA ASVLSNLSQF
     AGVVLTPRRS HVFKQIEFMR LSDKRILLII VTPEGDVQNR IMATQRDFSP SQLVEASNYI
     NAHFAGLSFD DVRRRLREEI DALRGDMTTL MHAAVTASTD ESDTGETVLI SGERNLLEVA
     DLSSDMARLR KLFDVFDQKT SLLQLLDVSS HAAGVQIFIG GESNLVPIEE MSVVTAPYEV
     NGKIVGTLGV IGPTRMAYNR VIPIVDITAR LLSLTLSQQ