ID   HRCA_PARTM              Reviewed;         344 AA.
AC   Q9F1W4;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
OS   Parageobacillus thermoglucosidasius (Geobacillus thermoglucosidasius).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Parageobacillus.
OX   NCBI_TaxID=1426;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11114912; DOI=10.1128/jb.183.1.155-161.2001;
RA   Watanabe K., Yamamoto T., Suzuki Y.;
RT   "Renaturation of Bacillus thermoglucosidasius HrcA repressor by DNA and
RT   thermostability of the HrcA-DNA complex in vitro.";
RL   J. Bacteriol. 183:155-161(2001).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AB039833; BAB20746.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9F1W4; -.
DR   SMR; Q9F1W4; -.
DR   STRING; 1426.AOT13_17000; -.
DR   eggNOG; COG1420; Bacteria.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182450"
SQ   SEQUENCE   344 AA;  39138 MW;  18BEE37D56F290B2 CRC64;
     MLTDRQLLIL QVIIDDFIRS GQPVGSRALS KKHEISLSSA TIRNEMADLE ELGYIEKTHA
     SSGRVPSEKG YRYYVDHLLS PQRLTQEDIQ KIKSIFAERI YDLEKVVQKS AQILSDLTNY
     TSIALGPAVK DNKLKRIQII PLNKQTAVAI IVTDTGHVKN HVITVPASVD PSDLEKMVNI
     LNERLIGVPL IDLKDKIYKE VADVLRMHIH NYDSMLKTIA DTLDIPQEEK MFFAGKTNML
     NQPEFSDIQK VRSLMKMIEQ EKDFYRLLRK HNRKGIQVTI GRENQLSGME NCSLITATYS
     IGKEQLGTIA ILGPTRMEYS RVITILNRVA SDLSTVLTKW YQNN