ID   HRCA_PARUW              Reviewed;         385 AA.
AC   Q6MB28;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=pc1497;
OS   Protochlamydia amoebophila (strain UWE25).
OC   Bacteria; Chlamydiae; Parachlamydiales; Parachlamydiaceae;
OC   Candidatus Protochlamydia.
OX   NCBI_TaxID=264201;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UWE25;
RX   PubMed=15073324; DOI=10.1126/science.1096330;
RA   Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U.,
RA   Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T.,
RA   Mewes H.-W., Wagner M.;
RT   "Illuminating the evolutionary history of chlamydiae.";
RL   Science 304:728-730(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX908798; CAF24221.1; -; Genomic_DNA.
DR   RefSeq; WP_011176043.1; NC_005861.1.
DR   AlphaFoldDB; Q6MB28; -.
DR   SMR; Q6MB28; -.
DR   STRING; 264201.pc1497; -.
DR   EnsemblBacteria; CAF24221; CAF24221; PC_RS07175.
DR   KEGG; pcu:PC_RS07175; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000529; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..385
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182518"
SQ   SEQUENCE   385 AA;  44392 MW;  7BFC85D666950FB4 CRC64;
     MKIIKPTPIK RVGKHDRERR VLLGLVDYYI QTGKPVGSNT LKEAGFEDLS SATIRNYFAQ
     LEEEGYLLQS HSSGGRIPTD LAYRIYAHAY LNTNEPYPKQ NPFEAFKSFE SKEIAIFLQE
     AAEKLSWETN CAVFLSAPRF DHDFIANLKL VPLDAYRCLC IIMTDFGVIK TEVMHLPVKL
     SSFGIKRIEN YFHCRLTNLG EPENLEPEEE TVAQTFYNEL MLRYIVGYSN FIDVDLYRTG
     FSRLLFYSDF QDTNLLASSL SLFENAHSMR LLLKECKALN HLRFWIGDDL SSFANSSPRC
     SVLTIPYYIN YKPVGAVGLL GPTRLPYRAL FSLLKLFSDC ISETVTKNVY KFKIDYRQPE
     QSLYLKKEES LLIGQSRFLI EDKRP