ID   HRCA_PELTS              Reviewed;         348 AA.
AC   A5D3X8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=PTH_0875;
OS   Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Desulfotomaculaceae;
OC   Pelotomaculum.
OX   NCBI_TaxID=370438;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13744 / JCM 10971 / SI;
RX   PubMed=18218977; DOI=10.1101/gr.7136508;
RA   Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.;
RT   "The genome of Pelotomaculum thermopropionicum reveals niche-associated
RT   evolution in anaerobic microbiota.";
RL   Genome Res. 18:442-448(2008).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AP009389; BAF59056.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5D3X8; -.
DR   SMR; A5D3X8; -.
DR   STRING; 370438.PTH_0875; -.
DR   EnsemblBacteria; BAF59056; BAF59056; PTH_0875.
DR   KEGG; pth:PTH_0875; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000006556; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..348
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000075290"
SQ   SEQUENCE   348 AA;  39560 MW;  87973A18B8F27F71 CRC64;
     MKLDDRKQKV LLAIVHDYIA TAEPVGSRTI AKKYKLGVSP ATIRNEMADL EEMGYIEQPH
     TSAGRIPSER GYRYYVDYLM KRQELSREEE ELIRREYEAK VRDVGQVIQK TGQLLSQLTN
     YTAVVLSPQI ESSRFKYIQL VSMHPSQAMV IVVMDNGIVH NRMIEVPESI TCADMETISR
     VLNAKLRGLT MESIRLTLMK EIYFELARHK HILDLAMELI QDSLLHKVED KIYLGGVFNM
     LNQPEFHDVE KVKTLLGILE QEKLLRDLIT SGGSEEGVTV RIGGEIMHED IRECSMVTAP
     YSVCGRKIGS LGVLGPTRME YAKVVSVVDF MTKNLSQVLE RIVRGTGR