ID   HRCA_POLNA              Reviewed;         337 AA.
AC   A1VKP8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Pnap_0909;
OS   Polaromonas naphthalenivorans (strain CJ2).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Polaromonas.
OX   NCBI_TaxID=365044;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CJ2;
RX   PubMed=19453698; DOI=10.1111/j.1462-2920.2009.01947.x;
RA   Yagi J.M., Sims D., Brettin T., Bruce D., Madsen E.L.;
RT   "The genome of Polaromonas naphthalenivorans strain CJ2, isolated from coal
RT   tar-contaminated sediment, reveals physiological and metabolic versatility
RT   and evolution through extensive horizontal gene transfer.";
RL   Environ. Microbiol. 11:2253-2270(2009).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000529; ABM36226.1; -; Genomic_DNA.
DR   RefSeq; WP_011800320.1; NC_008781.1.
DR   AlphaFoldDB; A1VKP8; -.
DR   SMR; A1VKP8; -.
DR   STRING; 365044.Pnap_0909; -.
DR   EnsemblBacteria; ABM36226; ABM36226; Pnap_0909.
DR   KEGG; pna:Pnap_0909; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_4; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000644; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..337
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118310"
SQ   SEQUENCE   337 AA;  37202 MW;  B68CB6011540BD65 CRC64;
     MLDSRARLLL KALVERYIAD GQPVGSRTLS KASGLELSPA TIRNVMSDLE DLGLIVSPHT
     SAGRIPTARG YRLFVDTMLT TQRDPFSVAG QMARIAPDQP LKVISNAAHM LSSLSQFVGV
     VMAPRRTSVF RHIEFLRLSE KRFLVIIVSP DGDVQNRVIF TETDYTASQL IEASNFLNSH
     YAGMAIEEVR ERLKNEVEAL RGEIATLMQE AVLVSSEAIE SRDEVVVSGE RNLLAVSDFS
     SDMGNLRKLF DLFEQKAQLM RLLDVSSRAE GVRIYIGGES QVIPYQELSV VTAPYEVDGQ
     VVGTLGVIGP MRMPYEKMIQ IVDITSKLVS TALSHSK