ID   HRCA_PROA2              Reviewed;         355 AA.
AC   B4S9D2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Paes_1584;
OS   Prosthecochloris aestuarii (strain DSM 271 / SK 413).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Prosthecochloris.
OX   NCBI_TaxID=290512;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 271 / SK 413;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F., Overmann J.,
RA   Bryant D.A., Richardson P.;
RT   "Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001108; ACF46602.1; -; Genomic_DNA.
DR   RefSeq; WP_012506135.1; NC_011059.1.
DR   AlphaFoldDB; B4S9D2; -.
DR   SMR; B4S9D2; -.
DR   STRING; 290512.Paes_1584; -.
DR   EnsemblBacteria; ACF46602; ACF46602; Paes_1584.
DR   KEGG; paa:Paes_1584; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_10; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000002725; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..355
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092826"
SQ   SEQUENCE   355 AA;  39782 MW;  19789BD053F393D4 CRC64;
     MKTIDLTPRE REVLGIIIQA YVVSASPVSS RFIAKNYNLG LSDATIRNVM ADLEDAGFIS
     QPHTSAGRVP TDKGYRYYVD LIMMVQGIDD DEKRHIDSNL RLFTIDRKDS SEVLFAAAKV
     LGSISQQLSV VMSPRLSLGV FERLDMVLLS SSRIMVILSI QSLFVKTIVM ELDLDVSRRQ
     IEMVVDLLNQ RLSGLTLDEI RTSIAERLAD CDTDQGLLNR IVRSADELFD ESPVLDRLYI
     AGAEYIVSQP EFDQPQKVRD LICMIEDKTR IARIVDLDGV VVPQVMTERD VSITIGRENP
     ASTEGDFTVV TTPYFVGNTM GRLAVLGPKR MDYARVVRVV NYMADRLSTT FSDVN