ID   HRCA_PROMM              Reviewed;         352 AA.
AC   Q7V4D3;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=PMT_2026;
OS   Prochlorococcus marinus (strain MIT 9313).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=74547;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9313;
RX   PubMed=12917642; DOI=10.1038/nature01947;
RA   Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A.,
RA   Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L.,
RA   Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C.,
RA   Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R.,
RA   Chisholm S.W.;
RT   "Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche
RT   differentiation.";
RL   Nature 424:1042-1047(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BX548175; CAE22200.1; -; Genomic_DNA.
DR   RefSeq; WP_011131391.1; NC_005071.1.
DR   AlphaFoldDB; Q7V4D3; -.
DR   SMR; Q7V4D3; -.
DR   STRING; 74547.PMT_2026; -.
DR   EnsemblBacteria; CAE22200; CAE22200; PMT_2026.
DR   KEGG; pmt:PMT_2026; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_2_0_3; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001423; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..352
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182520"
SQ   SEQUENCE   352 AA;  38205 MW;  BA90B7E435DBCB34 CRC64;
     MTEHKRRATP PYHQDPDVTA LESLPARQQQ VLQATVHHYV DTIEPVGSKT LVQRFGLKAS
     AATVRSAMGA LEQRGLLTQP HTSAGRVPSP QGYRHYVDCL LPPPGSAAQH LERELTNLSL
     RWAALDDLMW QLARRLTDFT GLMSLITRPA RPKPTLQAVR LVRSGDRLLV MLVESSNQAS
     HLNLRLPHEA SNELEAIEEW TRDQLATTGN GSLDWSSLPP QLNLSGSLLR EAIHSHSQAQ
     TPAESDAVFH GMSRLLAQPE FSSSASLQPL LELMDTQPAA VVPVGSEQLG GVWIGAEHPK
     SALEACSVVQ APYHSSGEGI GQVALVGPMR MAYATAKAAV SSVANHLERL LC