ID   HRCA_RALSO              Reviewed;         352 AA.
AC   Q8XW26;
DT   13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=RSc2649;
GN   ORFNames=RS04567;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AL646052; CAD16356.1; -; Genomic_DNA.
DR   RefSeq; WP_011002559.1; NC_003295.1.
DR   AlphaFoldDB; Q8XW26; -.
DR   SMR; Q8XW26; -.
DR   STRING; 267608.RSc2649; -.
DR   EnsemblBacteria; CAD16356; CAD16356; RSc2649.
DR   GeneID; 60502152; -.
DR   KEGG; rso:RSc2649; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_4; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001436; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..352
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182521"
SQ   SEQUENCE   352 AA;  38376 MW;  672E592CCA7154D0 CRC64;
     MDKRATILLK TLIERYIAEG QPVGSRTLSK YSGLDLSPAT IRNVMSDLEE MGFIASPHTS
     AGRVPTPRGY RLFVDTMLTA GPLDILGMHD RMAQQIAGTI AEQVRAQLAS HGSESSQRVI
     AAAAQTLSNL SQFAGIVMTP RRTHAFRQIE FLRLSETRIL LIVVTPEGDV QNRIIHTDTP
     YTPSQLVEAA NYINAHYGGM TFDAVRERLR GELNALQADM TSLMQAAVEA GSSAVSDEDP
     VVISGERKLL EVEDLSSSMD KLRRLFAVFE QKTGLLQLLD VSSRAEGVQI FIGGESSLVP
     HEDMAVITAP YEVDGKIVGT LGVIGPMRMA YERVIPIVDI TAKLLSSTLS QH