ID   HRCA_RHIE6              Reviewed;         362 AA.
AC   B3PZA3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=RHECIAT_CH0000403;
OS   Rhizobium etli (strain CIAT 652).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=491916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIAT 652;
RA   Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P.,
RA   Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J.,
RA   Palacios R., Davila G.;
RT   "Genome diversity and DNA divergence of Rhizobium etli.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001074; ACE89397.1; -; Genomic_DNA.
DR   RefSeq; WP_012482407.1; NC_010994.1.
DR   AlphaFoldDB; B3PZA3; -.
DR   SMR; B3PZA3; -.
DR   PRIDE; B3PZA3; -.
DR   EnsemblBacteria; ACE89397; ACE89397; RHECIAT_CH0000403.
DR   GeneID; 45955773; -.
DR   KEGG; rec:RHECIAT_CH0000403; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000008817; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..362
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092827"
SQ   SEQUENCE   362 AA;  39483 MW;  6B950F714CA5AA31 CRC64;
     MGTRSTSVSD AVAVLDERSR EIFRRIVEGY LESGEPLGSR NLSRLLPMSL SPASVRNVMS
     DLEELGLIYS PHISAGRLPT QIGLRFFVDA FMQVGDLSAE DRANIDRQVR AESGGNPVES
     MMNEASRMLS GISRGAGLVI TSKSDPVLKH VEFIRLEPTK ALAVLVGDHD QVENRIIELP
     AGVTSSQLTE AANFLNAHMS GQTLPELRKQ LSQLKDDVRH ELDALSRDLV ERGIAVWAGS
     PDEGKPAQLI IRGRANLLEG LGGAEDLDRL RMLFDDLEKK DSLIEILSLA ESGSGVRIFI
     GSENKLFSLS GSSLIVAPYR DDDDRIVGAV GVIGPTRLNY SRIVPMVDYT AQLVSRLSRN
     PL