ID   HRCA_RHILO              Reviewed;         360 AA.
AC   Q98DN7;
DT   13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=mll4621;
OS   Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS   (Mesorhizobium loti (strain MAFF 303099)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX   PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y.,
RA   Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y.,
RA   Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BA000012; BAB51233.1; -; Genomic_DNA.
DR   RefSeq; WP_010912575.1; NC_002678.2.
DR   AlphaFoldDB; Q98DN7; -.
DR   SMR; Q98DN7; -.
DR   STRING; 266835.14024630; -.
DR   EnsemblBacteria; BAB51233; BAB51233; BAB51233.
DR   GeneID; 66681023; -.
DR   KEGG; mlo:mll4621; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000552; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..360
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182522"
SQ   SEQUENCE   360 AA;  39209 MW;  C4CEBE8A6C5383B8 CRC64;
     MTKAIDPGSQ PLALQSLDMR SRDIFRRIVD SYLRDGEPVG SRSLSRILPS SLSPATIRNV
     MSDLEHLGLI YAPHISAGRL PTQAGLRFFV DAFMELGDLS DEERRTIEAQ VRASGSGATL
     EHMLTEASQM LSGMSRGAGL VLAAKNEVAL KHIEFIQLEP TKALAVLVSQ NGDVENRVVE
     LPAGITVSQL HEASNFLNAH IRGRTLAEAR TEIARIKEET RAALDTLSQD LVEKGLAVWA
     GAESGLPARL IVRGRANLLE NVTAQADIEL LRHLFEDMET QDGLIQLLDL AEQGSGVRIF
     IGSENKLFSL SGSSLVVAPY RDKDARVVGA LGVIGPTRLN YARIVPMVDY TAQLISRMLR