ID   HRCA_RHILW              Reviewed;         362 AA.
AC   B5ZMW9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Rleg2_0007;
OS   Rhizobium leguminosarum bv. trifolii (strain WSM2304).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395492;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM2304;
RX   PubMed=21304679; DOI=10.4056/sigs.44642;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K., Tiwari R.,
RA   Malfatti S., Kiss H., Lapidus A., Copeland A., Nolan M., Land M.,
RA   Ivanova N., Mavromatis K., Markowitz V., Kyrpides N., Melino V., Denton M.,
RA   Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv trifolii strain
RT   WSM2304, an effective microsymbiont of the South American clover Trifolium
RT   polymorphum.";
RL   Stand. Genomic Sci. 2:66-76(2010).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001191; ACI53310.1; -; Genomic_DNA.
DR   RefSeq; WP_003570826.1; NC_011369.1.
DR   AlphaFoldDB; B5ZMW9; -.
DR   SMR; B5ZMW9; -.
DR   STRING; 395492.Rleg2_0007; -.
DR   EnsemblBacteria; ACI53310; ACI53310; Rleg2_0007.
DR   KEGG; rlt:Rleg2_0007; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008330; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..362
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092828"
SQ   SEQUENCE   362 AA;  39432 MW;  E9A5E42B59AC7D07 CRC64;
     MGIRSTSVSD AVAALDERSR EIFRRIVEGY LESGEPLGSR NLSRLLPMSL SPASVRNVMS
     DLEDLGLIYS PHISAGRLPT QIGLRFFVDA FMQVGDLSAE DRASIDRQVR AESGGNPVES
     MMNEASRMLS GISRGAGLVI TSKSDPVLKH VEFIRLEPTK ALAVLVGDHD QVENRIIELP
     AGVTSSQLAE AANFLNAHMS GQTLPELRKQ LSQLKDNVRH ELDALSRDLV ERGIAVWAGS
     PDEGKPAQLI IRGRANLLEG LAGAEDLDRL RLLFDDLEKK DSLIEILNLA ETGSGVRIFI
     GSENKLFSLS GSSLIVAPYR DDDDRIVGAV GVIGPTRLNY SRIVPMVDYT AQLVSRLSRN
     PL