ID   HRCA_RHIRD              Reviewed;         363 AA.
AC   P0A3I9; O68443;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
OS   Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium
OS   radiobacter).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=358;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GV3101;
RX   PubMed=10601208; DOI=10.1128/jb.181.24.7509-7515.1999;
RA   Nakahigashi K., Ron E.Z., Yanagi H., Yura T.;
RT   "Differential and independent roles of a sigma32 homolog (RpoH) and an HrcA
RT   repressor in the heat shock response of Agrobacterium tumefaciens.";
RL   J. Bacteriol. 181:7509-7515(1999).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AF039940; AAC18052.1; -; Genomic_DNA.
DR   RefSeq; WP_006310175.1; NZ_JMKN01000003.1.
DR   AlphaFoldDB; P0A3I9; -.
DR   SMR; P0A3I9; -.
DR   STRING; 1082932.ATCR1_04989; -.
DR   PRIDE; P0A3I9; -.
DR   PATRIC; fig|358.65.peg.875; -.
DR   eggNOG; COG1420; Bacteria.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..363
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182438"
SQ   SEQUENCE   363 AA;  39900 MW;  898EF6B1C7AFA0F8 CRC64;
     MGFSAPLSKD QASLLDERSR EIFRRIVEGY LDTGEPLGSR SLSRLLPMSL SPASVRNVMS
     DLEELGLIYS PHISAGRLPT QTGLRFFVDA FMQVGDLPAD ERANIDRQIG PVAGHEQSLE
     GLLTEASRML SGMSRGAGLV LTAKNDVILK HVEFIRLEPT KALAVLVGDH NQVENRIIEL
     PAGISSSQLT EAANFINAHL SGQTLQELRG QFQTQRTELQ SELGMLAQDL VERGLAIWAG
     DNEEGKLGRL IVRGRSNLLE GLAGEEDIDR VRMLFDDLER KENLIEILNL AESGSGVRIF
     IGSENKLFSL SGSSLIVAPY RDEENRVVGA VGVIGPTRLN YARIVPMVDY TAQIMARLSR
     KQR