ID   HRCA_RHOE4              Reviewed;         347 AA.
AC   C1A1G4;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=RER_37410;
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus;
OC   Rhodococcus erythropolis group.
OX   NCBI_TaxID=234621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT   PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AP008957; BAH34449.1; -; Genomic_DNA.
DR   RefSeq; WP_019749027.1; NC_012490.1.
DR   AlphaFoldDB; C1A1G4; -.
DR   SMR; C1A1G4; -.
DR   STRING; 234621.RER_37410; -.
DR   EnsemblBacteria; BAH34449; BAH34449; RER_37410.
DR   GeneID; 57486352; -.
DR   KEGG; rer:RER_37410; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..347
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000202553"
SQ   SEQUENCE   347 AA;  37016 MW;  C19FB38CEAD5E421 CRC64;
     MSSTDDRRFE VLRAIVADYV STQDPVGSKA LVERHNLGVS SATVRNDMAF LEAEGYIAQP
     HTSSGRVPTD KGYREFVDRI ADVKPMSGPE RRAILEFLES GVDLDDVLRR GVRLLAQLTR
     QVAVVQYPSL SASSVRHLEV VALTPARLLL VLITDSGRVD QRIVELGDVL EDEDLSRLRA
     LLGGALEGKR LAAASIAVAE LADESPADLR DAVIRSATVL VETLVEHPED RLVLGGTSNL
     TRNAADFSGL AGFPGSLRAV LEALEEQVVV LKLLAATQNS GTVTVQIGEE TQVEQMRGTS
     VISTGYGAAG TVFGGVGVLG PTRMDYPGTI ASVAAVARYI GEVLSER