ID   HRCA_RHOJR              Reviewed;         347 AA.
AC   Q0SHB5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=RHA1_ro01247;
OS   Rhodococcus jostii (strain RHA1).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=101510;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHA1;
RX   PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA   McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C.,
RA   Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H.,
RA   Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H.,
RA   Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R.,
RA   Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W.,
RA   Eltis L.D.;
RT   "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT   catabolic powerhouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000431; ABG93071.1; -; Genomic_DNA.
DR   RefSeq; WP_011594328.1; NC_008268.1.
DR   AlphaFoldDB; Q0SHB5; -.
DR   SMR; Q0SHB5; -.
DR   STRING; 101510.RHA1_ro01247; -.
DR   EnsemblBacteria; ABG93071; ABG93071; RHA1_ro01247.
DR   KEGG; rha:RHA1_ro01247; -.
DR   PATRIC; fig|101510.16.peg.1273; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000008710; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..347
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010445"
SQ   SEQUENCE   347 AA;  37053 MW;  96088CF2A7B9A08F CRC64;
     MSSTDDRRFE VLRAIVADYV STQEPVGSKA LVERHNLGVS SATVRNDMAF LESEGYIAQP
     HTSSGRVPTD KGYRQFVDRI ADVKPLSTAE RRAILEFLES GVDLDDVLRR GVRLLAQLTR
     QVAVVQYPTL SASSVRHLEV VALTPARLLL VLITDSGRVD QRIVELGDVL DDEDLARLRG
     LLGGALDGKR LAAASIAVSE LADEAPEDLR DAVVRSATVL VETLVEHPEE RLVLGGTANL
     TRNAADFSGI SGFPGSLRAV LEALEEQVVV LKLLAATQDA GTVTVRIGEE TQVEQMRGTS
     VISTGYGAAG TVLGGMGVLG PTRMDYPGTI ASVAAVARYI GQVLAER