ID   HRCA_RHOOB              Reviewed;         347 AA.
AC   C1AUK7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=ROP_09680;
OS   Rhodococcus opacus (strain B4).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=632772;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B4;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT   PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AP011115; BAH49215.1; -; Genomic_DNA.
DR   RefSeq; WP_012688203.1; NC_012522.1.
DR   AlphaFoldDB; C1AUK7; -.
DR   SMR; C1AUK7; -.
DR   STRING; 632772.ROP_09680; -.
DR   EnsemblBacteria; BAH49215; BAH49215; ROP_09680.
DR   KEGG; rop:ROP_09680; -.
DR   PATRIC; fig|632772.20.peg.1033; -.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000002212; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..347
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118314"
SQ   SEQUENCE   347 AA;  37053 MW;  7EB8E7F6B7ADF1CA CRC64;
     MSSTDDRRFE VLRAIVADYV STQEPVGSKA LVERHNLGVS SATVRNDMAF LESEGYIAQP
     HTSSGRVPTD KGYRQFVDRI ADVKPLSTAE RRAILDFLES GVDLDDVLRR GVRLLAQLTR
     QVAVVQYPTL SASSVRHLEV VALTPARLLL VLITDSGRVD QRIVELGDVL DDEDLARLRG
     LLGGALDGKR LAAASIAVSE LADEAPEDLR DAVVRSATVL VETLVEHPEE RLVLGGTANL
     TRNAADFTGI SGFPGSLRAV LEALEEQVVV LKLLAATQDA GTVTVRIGEE TQVEQMRGTS
     VISTGYGAAG TVLGGMGVLG PTRMDYPGTI ASVAAVARYI GQVLAER