ID   HRCA_RHOPA              Reviewed;         362 AA.
AC   Q6NCY7;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=RPA0330;
OS   Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=258594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-98 / CGA009;
RX   PubMed=14704707; DOI=10.1038/nbt923;
RA   Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L.,
RA   Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R.,
RA   Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C.,
RA   Harrison F.H., Gibson J., Harwood C.S.;
RT   "Complete genome sequence of the metabolically versatile photosynthetic
RT   bacterium Rhodopseudomonas palustris.";
RL   Nat. Biotechnol. 22:55-61(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BX572594; CAE25774.1; -; Genomic_DNA.
DR   RefSeq; WP_011155898.1; NC_005296.1.
DR   AlphaFoldDB; Q6NCY7; -.
DR   SMR; Q6NCY7; -.
DR   STRING; 258594.RPA0330; -.
DR   PRIDE; Q6NCY7; -.
DR   EnsemblBacteria; CAE25774; CAE25774; RPA0330.
DR   GeneID; 66891341; -.
DR   KEGG; rpa:RPA0330; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; Q6NCY7; -.
DR   BioCyc; RPAL258594:TX73_RS01710-MON; -.
DR   Proteomes; UP000001426; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..362
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182524"
SQ   SEQUENCE   362 AA;  39044 MW;  4E33A2A0339A9014 CRC64;
     MAQHDPIGLI APNAGLAQLN ERSREIFRQI VESYLATGEP VGSRNISRLI SVPLSPASVR
     NVMADLEQLG LIYAPHTSAG RLPTELGLRF FVDALMQIGD LTEPERQSIQ AQLSSVGRAH
     TVEAALGEAL TRLSGLTRAA AVVLTAKANV RLKHIEFVRL EPERALVILV AEDGQVENRV
     LTLPPGVPSS ALIEAANYLN ARIRGRTLAE ARLELESLMV QNKAELDQLT QKVIAAGIAS
     WSGGDGEDRQ LIVRGHANLL EDLHALDDLE RVRLLFDDLE TKRGVIDLLG RAESADGVRI
     FIGSENKLFS LSGSSTIIAP YSDGAGHIVG VLGVIGPTRL NYARVIPMVD YTARIVSRML
     GG