ID   HRCA_ROSCS              Reviewed;         359 AA.
AC   A7NS62;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Rcas_4390;
OS   Roseiflexus castenholzii (strain DSM 13941 / HLO8).
OC   Bacteria; Chloroflexi; Chloroflexia; Chloroflexales; Roseiflexineae;
OC   Roseiflexaceae; Roseiflexus.
OX   NCBI_TaxID=383372;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13941 / HLO8;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P.;
RT   "Complete sequence of Roseiflexus castenholzii DSM 13941.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000804; ABU60408.1; -; Genomic_DNA.
DR   RefSeq; WP_012122829.1; NC_009767.1.
DR   AlphaFoldDB; A7NS62; -.
DR   SMR; A7NS62; -.
DR   STRING; 383372.Rcas_4390; -.
DR   EnsemblBacteria; ABU60408; ABU60408; Rcas_4390.
DR   KEGG; rca:Rcas_4390; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000263; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..359
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000075292"
SQ   SEQUENCE   359 AA;  40311 MW;  FD704F2EF1E1D857 CRC64;
     MTTDLTDRRQ LILKLAIQEF IESSQPVASE LLVRKYRLNV SPATVRNELA ALEELGYLTH
     LHTSAGRVPT DAGYRYFVEN LMDRTPLSAT EQRTIRHQFY QVRSELDQWI QLAGAVLART
     AQNASVVTPP RAQQARLKHL ELISIHDTTA LMVLVLHDGT IRQQTLTLDM ALSQEELSRR
     ASRINERCAD APVERVEEFL KQERAHEPPG GDALACQVLD LIVKAMHQFN EHLNSDIHSD
     GLIEILNQPE FSQVERVRRM IEILQSRRAL GTLIPRALSS SGVQVVIGGE HSYDEMREYS
     VVLSRYGGGE IVGVLGVIGP TRMAYPRAIS AVRYISAVMS DLLAELYGIE GDTHWEVES