ID   HRCA_ROSS1              Reviewed;         359 AA.
AC   A5UYW7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=RoseRS_3462;
OS   Roseiflexus sp. (strain RS-1).
OC   Bacteria; Chloroflexi; Chloroflexia; Chloroflexales; Roseiflexineae;
OC   Roseiflexaceae; Roseiflexus.
OX   NCBI_TaxID=357808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.;
RT   "Complete sequence of Roseiflexus sp. RS-1.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000686; ABQ91820.1; -; Genomic_DNA.
DR   RefSeq; WP_011958162.1; NC_009523.1.
DR   AlphaFoldDB; A5UYW7; -.
DR   SMR; A5UYW7; -.
DR   STRING; 357808.RoseRS_3462; -.
DR   EnsemblBacteria; ABQ91820; ABQ91820; RoseRS_3462.
DR   KEGG; rrs:RoseRS_3462; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000006554; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..359
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010446"
SQ   SEQUENCE   359 AA;  40014 MW;  48B071F4CE3DF80D CRC64;
     MTTDLTDRRR LILKLAIQEF IESSQPVASD LLVRKYRLNV SPATVRNELA ALEELGYLTH
     LHTSAGRVPT DAGYRYFVEN LMDRTPLSAT EQRTIRHQFY QVRSELDQWI QLAGAVLART
     AQNASVVTPP RAQQARLKHL ELIAIHETTA LMVLVLHDGT IRQQTLTLDV AMTQEELSRC
     AAQINERCCD APVERIEEVL KQERAQEPPG GNALVCQVLD LVVKAMHQFN EHISSDIHSD
     GLIEILNQPE FSRVERVRRM VEILQSGRAL GTLIPRALSS SGVQVVIGGE HSYDEMREYS
     VVLSRYGGGE IVGVLGVIGP TRMAYPRAIS AVRYISAVMS DLLAELYGIE GANRLNSEP