ID   HRCA_SINFN              Reviewed;         359 AA.
AC   C3MEJ2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=NGR_c00110;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/aem.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT   systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001389; ACP23815.1; -; Genomic_DNA.
DR   RefSeq; WP_012706600.1; NC_012587.1.
DR   RefSeq; YP_002824568.1; NC_012587.1.
DR   AlphaFoldDB; C3MEJ2; -.
DR   SMR; C3MEJ2; -.
DR   STRING; 394.NGR_c00110; -.
DR   PRIDE; C3MEJ2; -.
DR   EnsemblBacteria; ACP23815; ACP23815; NGR_c00110.
DR   KEGG; rhi:NGR_c00110; -.
DR   PATRIC; fig|394.7.peg.2801; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001054; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..359
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118312"
SQ   SEQUENCE   359 AA;  39413 MW;  6296EE27CE3B3D19 CRC64;
     MVLRNPEKKG IASTLDERSG EIFRRIVETY LESGEPLGSR NLSRLLPMSL SPASVRNVMS
     DLEDLGLIYS PHVSAGRLPT QTGLRFFVDA FMQVGNLSAE ERTSIERQVR RADRDQPIDS
     LLAEASQMLS GMSRGAGLVI TTKSDPVLKH VEFIRLAPTK ALAVLVGDHD QVENRIIELP
     AGITSAQLTE AANFVNAHLA GQTIPELRSQ LEKVKETVRG ELDALSQDLV ERGLAIWSGS
     EGDEKPARLI VRGRANLLEG LEGTEDIERL RMLFDDLEKK DSLIELLDLA ESGPGVRIFI
     GSENKLFSLS GSSLIVAPYR DSDDRIVGAV GVIGPTRLNY SRIVPMVDYT AQLMSRLSR