ID   HRCA_SINMW              Reviewed;         359 AA.
AC   A6U5E1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Smed_0011;
OS   Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=366394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM419;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA   Richardson P.;
RT   "Complete sequence of Sinorhizobium medicae WSM419 chromosome.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000738; ABR58871.1; -; Genomic_DNA.
DR   RefSeq; WP_011974226.1; NC_009636.1.
DR   RefSeq; YP_001325706.1; NC_009636.1.
DR   AlphaFoldDB; A6U5E1; -.
DR   SMR; A6U5E1; -.
DR   STRING; 366394.Smed_0011; -.
DR   EnsemblBacteria; ABR58871; ABR58871; Smed_0011.
DR   GeneID; 61611139; -.
DR   KEGG; smd:Smed_0011; -.
DR   PATRIC; fig|366394.8.peg.3066; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001108; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..359
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010447"
SQ   SEQUENCE   359 AA;  39189 MW;  44054B5A5A2248C2 CRC64;
     MVLRNPDKKG IASALDERSG EIFRRIVESY LESGEPLGSR NLSRLLPISL SPASVRNVMS
     DLEDLGLIYS PHVSAGRLPT QTGLRFFVDA FMQVGNLSPE ERASIERQVG PGNRDHSVEN
     LLTEASQMLS GMSRGAGLVI TTKSDPVLKH VEFIRLAPTK ALAVLVGEHD QVENRIIELP
     AGITSAQLTE AANFVNAHLA GQTIPELRTQ LEKVKETVRG ELDALSQDLV ERGLAIWSGS
     EGDGQPARLI VRGRANLLEG LEGTEDIERL RMLFDDLEKK DSLIEILNLA ESGPGVRIFI
     GSENKLFSLS GSSLIVAPYR DSDDRIVGAV GVIGPTRLNY SRIVPMVDYT AQLMSRMSR