ID   HRCA_STAA8              Reviewed;         325 AA.
AC   Q2FXZ0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=SAOUHSC_01685;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000253; ABD30759.1; -; Genomic_DNA.
DR   RefSeq; WP_000627140.1; NZ_LS483365.1.
DR   RefSeq; YP_500195.1; NC_007795.1.
DR   AlphaFoldDB; Q2FXZ0; -.
DR   SMR; Q2FXZ0; -.
DR   STRING; 1280.SAXN108_1608; -.
DR   EnsemblBacteria; ABD30759; ABD30759; SAOUHSC_01685.
DR   GeneID; 3921797; -.
DR   KEGG; sao:SAOUHSC_01685; -.
DR   PATRIC; fig|93061.5.peg.1533; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   PRO; PR:Q2FXZ0; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..325
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010451"
SQ   SEQUENCE   325 AA;  37016 MW;  A83F42A60AD24D82 CRC64;
     MITDRQLSIL NAIVEDYVDF GQPVGSKTLI ERHNLNVSPA TIRNEMKQLE DLNYIEKTHS
     SSGRSPSQLG FRYYVNRLLE QTSHQKTNKL RRLNQLLVEN QYDVSSALTY FADELSNISQ
     YTTLVVHPNH KQDIINNVHL IRANPNLVIM VIVFSSGHVE HVHLASDIPF NNDKLNTISN
     FVTNKLTEFN QNLQDDIVSF VQSEQEEIFI NKLLNTMNNH ISNQSNSIYM GGKVKLIDAL
     NESNVSSIQP ILQYIESNRI AELLQDISSP NINVKIGNEI DDSLSDISIV TSQYHFDETL
     KGQIAVIGPT AMHYQNVIQL LNRIW