ID   HRCA_STAAU              Reviewed;         325 AA.
AC   P68794; P45556;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=912;
RX   PubMed=8045913; DOI=10.1128/jb.176.15.4779-4783.1994;
RA   Ohta T., Saito K., Kuroda M., Honda K., Hirata H., Hayashi H.;
RT   "Molecular cloning of two new heat shock genes related to the hsp70 genes
RT   in Staphylococcus aureus.";
RL   J. Bacteriol. 176:4779-4783(1994).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- INDUCTION: By heat shock.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; D30690; BAA06357.1; -; Genomic_DNA.
DR   RefSeq; WP_000627144.1; NZ_WYDB01000002.1.
DR   AlphaFoldDB; P68794; -.
DR   SMR; P68794; -.
DR   OMA; DYPGTMG; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   2: Evidence at transcript level;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..325
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182530"
SQ   SEQUENCE   325 AA;  36989 MW;  A3BA2DDF0E98ED36 CRC64;
     MITDRQLSIL NAIVEDYVDF GQPVGSKTLI ERHNLNVSPA TIRNEMKQLE DLNYIEKTHS
     SSGRSPSQLG FRYYVNRLLE QTSHQKTNKL RRLNQLLVEN QYDVSSALTY FADELSNISQ
     YTTLVVHPNH KQDIINNVHL IRANPNLVIM VIVFSSGHVE HVHLASDIPF SNDKLNTISN
     FVTNKLTEFN QNLQDDIVSF VQSEQEEIFI NKLINTMNNH ISNQSNSIYM GGKVKLIDAL
     NESNVSSIQP ILQYIESNRI AELLQDISSP NINVKIGNEI DDSLSDISIV TSQYHFDETL
     KGQIAVIGPT AMHYQNVIQL LNRIW