ID   HRCA_STAAW              Reviewed;         325 AA.
AC   Q8NWA8;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=MW1534;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BA000033; BAB95399.1; -; Genomic_DNA.
DR   RefSeq; WP_000627140.1; NC_003923.1.
DR   AlphaFoldDB; Q8NWA8; -.
DR   SMR; Q8NWA8; -.
DR   EnsemblBacteria; BAB95399; BAB95399; BAB95399.
DR   KEGG; sam:MW1534; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..325
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182531"
SQ   SEQUENCE   325 AA;  37016 MW;  A83F42A60AD24D82 CRC64;
     MITDRQLSIL NAIVEDYVDF GQPVGSKTLI ERHNLNVSPA TIRNEMKQLE DLNYIEKTHS
     SSGRSPSQLG FRYYVNRLLE QTSHQKTNKL RRLNQLLVEN QYDVSSALTY FADELSNISQ
     YTTLVVHPNH KQDIINNVHL IRANPNLVIM VIVFSSGHVE HVHLASDIPF NNDKLNTISN
     FVTNKLTEFN QNLQDDIVSF VQSEQEEIFI NKLLNTMNNH ISNQSNSIYM GGKVKLIDAL
     NESNVSSIQP ILQYIESNRI AELLQDISSP NINVKIGNEI DDSLSDISIV TSQYHFDETL
     KGQIAVIGPT AMHYQNVIQL LNRIW