ID   HRCA_STACT              Reviewed;         322 AA.
AC   B9DNK2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Sca_1204;
OS   Staphylococcus carnosus (strain TM300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=396513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM300;
RX   PubMed=19060169; DOI=10.1128/aem.01982-08;
RA   Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C.,
RA   Goetz F.;
RT   "Genome analysis of the meat starter culture bacterium Staphylococcus
RT   carnosus TM300.";
RL   Appl. Environ. Microbiol. 75:811-822(2009).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AM295250; CAL28111.1; -; Genomic_DNA.
DR   RefSeq; WP_015900451.1; NC_012121.1.
DR   AlphaFoldDB; B9DNK2; -.
DR   SMR; B9DNK2; -.
DR   STRING; 396513.SCA_1204; -.
DR   GeneID; 60545106; -.
DR   KEGG; sca:SCA_1204; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   BioCyc; SCAR396513:SCA_RS06030-MON; -.
DR   Proteomes; UP000000444; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..322
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118315"
SQ   SEQUENCE   322 AA;  36633 MW;  44733C1F1920131C CRC64;
     MITNRQQSIL NAIVEDYVDY GLPVGSKTVI ERHQVNVSPA TIRNEMKILE GMGLIEKAHA
     SSGRSPSIKG FRYYVDQLLE NTSPRTEFNN QRLNKLLADY NYNLSNALSV YANELSMSTK
     YTTLIMKPNQ SKDLITDVHL FNTVAHLVIM VIVFESGNVE HLQLAVPEKI SKNRLVQIAN
     YIKSIFNADM RNDFSDETFM HSNDYLIVNQ LIDLLNQRLN DITTDIFFGG KANLIDTLNE
     QNVNSIQQIL QYLESNKILK LFEDDNHSGI DVKIGQEIDN GLEDISIILS DYHIDNHLKG
     HVAVIGPTAM RYQNVIQLLY KV