ID   HRCA_STAES              Reviewed;         325 AA.
AC   Q8CP15;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=SE_1269;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE015929; AAO04868.1; -; Genomic_DNA.
DR   RefSeq; NP_764824.1; NC_004461.1.
DR   RefSeq; WP_001831038.1; NZ_WBME01000008.1.
DR   AlphaFoldDB; Q8CP15; -.
DR   SMR; Q8CP15; -.
DR   STRING; 176280.SE_1269; -.
DR   EnsemblBacteria; AAO04868; AAO04868; SE_1269.
DR   GeneID; 50018615; -.
DR   KEGG; sep:SE_1269; -.
DR   PATRIC; fig|176280.10.peg.1238; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..325
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182532"
SQ   SEQUENCE   325 AA;  37204 MW;  EB73B8F2388DC8A0 CRC64;
     MITKRQLSIL NAIVEDYVDF GQPIGSKTLI HRHHLDVSPA TIRNEMKQLE EMHFIEKTHT
     SSGRVPSESG IRYYVNRLLE QTSHQSQNKI QRLNQLLIEN HYDSSTALTN FAHELSMKSQ
     YATLVVRPNH KQDVINDIHL IRANNHLIIL VMVFSSGHVE NIHFVSHAQL NNINLNKIAN
     FLTEHFSFNR KVLTQNIESY FSQKEELLLA NEVVEMINLQ IGNQSNSIYM GGKVKLIDAL
     NESNVSSIQP ILQYIESNKI TELLEDISTS QINVRIGKEI DDSLSDISIV TSQYHFDESL
     KGQIAVIGPT AMHYQNVIQL LNRIW