ID   HRCA_STAHJ              Reviewed;         325 AA.
AC   Q4L6T2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=SH1334;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AP006716; BAE04643.1; -; Genomic_DNA.
DR   RefSeq; WP_011275631.1; NC_007168.1.
DR   AlphaFoldDB; Q4L6T2; -.
DR   SMR; Q4L6T2; -.
DR   STRING; 279808.SH1334; -.
DR   EnsemblBacteria; BAE04643; BAE04643; SH1334.
DR   GeneID; 58062475; -.
DR   KEGG; sha:SH1334; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..325
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010453"
SQ   SEQUENCE   325 AA;  36869 MW;  DA79412877D39536 CRC64;
     MITQRQLSIL NAIVEDYVDL GQPIGSKALI DRHHLDVSPA TIRNEMKQLE DLNFLEKTHS
     SSGRSPSEEG FRLYVDQLLK QTSRQNKNKI QRLNQLLIEN HYDISSALSY FANELSMKSH
     YATLVVRPKH SEEMINNVHL IKANDSIMIL VIIYNSGHVE HFHLNSALEL SSDRLIAISN
     FISNNNIEIS AKLSDKIRSF ANSNEENQFI NDIVKMINSH ISKQSNSIFL GGKVKLIDAL
     NESNVSSIQP ILQYLESERI TELLQTISTN DINVKIGKEI DESLSDISIV TSQYHFDNSL
     KGQIAVIGPT AMRYQNVIQL LNQIW