ID   HRCA_STRAL              Reviewed;         338 AA.
AC   O52163;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
OS   Streptomyces albus G.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=J1074;
RX   PubMed=9748446; DOI=10.1128/jb.180.19.5129-5134.1998;
RA   Grandvalet C., Rapoport G., Mazodier P.;
RT   "hrcA, encoding the repressor of the groEL genes in Streptomyces albus G,
RT   is associated with a second dnaJ gene.";
RL   J. Bacteriol. 180:5129-5134(1998).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AF025656; AAC62528.1; -; Genomic_DNA.
DR   AlphaFoldDB; O52163; -.
DR   SMR; O52163; -.
DR   PRIDE; O52163; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..338
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182536"
SQ   SEQUENCE   338 AA;  36976 MW;  81C15F9A92BA7A49 CRC64;
     MLSERRLEVL RAIVQDYVGT EEPVGSKALT ERHRLGVSPA TVRNDMAALE DEGYIAQPHT
     SAGPIPTDKG YRLFVDRLAD VKPMTAPERR AIHHFLDQAV DLDDVVARTV RLLAHVTRQV
     AVVQYPSLTR STVRHVELLS MAPARLMLVL ITDTGRVEQR MIDCPAPFGE SSVADLRARL
     NSQVAGRRFA DVPQLVQDLP ESFESEDRPT VSTVLSTLLE TLVEETEERL MIGGTANLTR
     FGHDFPLTIR PVLEALEEQV VLLKLLGEAK DSAMTVRIGH ENAHEGLSST SVVSVGYGSG
     REAVAKLGVV GPTRMDYPGT MGAVRAVARY VGQILAES