ID   HRCA_STRCO              Reviewed;         338 AA.
AC   Q9RDD6;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=SCO2555;
GN   ORFNames=SCC77.22c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AL939113; CAB66233.1; -; Genomic_DNA.
DR   RefSeq; NP_626793.1; NC_003888.3.
DR   RefSeq; WP_003976249.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; Q9RDD6; -.
DR   SMR; Q9RDD6; -.
DR   STRING; 100226.SCO2555; -.
DR   GeneID; 1097989; -.
DR   KEGG; sco:SCO2555; -.
DR   PATRIC; fig|100226.15.peg.2600; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   InParanoid; Q9RDD6; -.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; Q9RDD6; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..338
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182538"
SQ   SEQUENCE   338 AA;  36575 MW;  12BD83F913E9F871 CRC64;
     MLSERRLKVL RAIVQDYVGT EEPVGSKALT ERHNLGVSPA TVRNDMAALE DEGFIAQPHT
     SAGRIPTDKG YRLFVDKLAG VKPMTAPERR AIQNFLEGAV DLDDVVARTV RLLAQLTRQV
     AVVQYPSLTR STVRHVELLS LAPARLMLVL ITDTGRVEQR MVDCPAPFGE ASLADLRARL
     NSRVAGRRFA DVPALVEDLA EPFEAEDRGT VSTVLSTLLE TLVEENEERL MIGGTANLTR
     FGHDFPLVIR PVLEALEEQV VLLKLLGEAK DPGVTVRIGH ENAHEGLNST SVVSVGYGSG
     GEAVAKLGVV GPTRMDYPGT MGAVRAVARY VGQILAES