ID   HRCA_STREM              Reviewed;         344 AA.
AC   B4U1A7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Sez_0400;
OS   Streptococcus equi subsp. zooepidemicus (strain MGCS10565).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=552526;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGCS10565;
RX   PubMed=18716664; DOI=10.1371/journal.pone.0003026;
RA   Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R.,
RA   Musser J.M.;
RT   "Genome sequence of a lancefield group C Streptococcus zooepidemicus strain
RT   causing epidemic nephritis: new information about an old disease.";
RL   PLoS ONE 3:E3026-E3026(2008).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001129; ACG61774.1; -; Genomic_DNA.
DR   RefSeq; WP_012515050.1; NC_011134.1.
DR   AlphaFoldDB; B4U1A7; -.
DR   SMR; B4U1A7; -.
DR   EnsemblBacteria; ACG61774; ACG61774; Sez_0400.
DR   KEGG; sez:Sez_0400; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001873; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092830"
SQ   SEQUENCE   344 AA;  38757 MW;  5403E8673F5DBF9B CRC64;
     MITERQSNIL NLIVDLFTQT HEPVGSKALQ SVIASSSATI RNDMAKLEKL GLLEKAHTSS
     GRMPSAAGFK YFVEHSLNLG SIDEQDFYQL VKAFDFEAFK LEDVLLRASQ MLSDMTGYTA
     AILDVEPARQ RLTGFDIVQL SSHDALAVLT LDESKPLTVQ FAIPKNFMNR DLLVLKGIVA
     DRLLGKDVMT VHYKLRTEIP QIVQKYFTVT DNVLDLFDYI FVGLFRETIF VSGKVAALDY
     AGLVTYQFLD EEQRLALSIR QSLSEEEMAT VQVADSSEPA LANVTLLTYK FLIPYRGFGL
     LSLIGPVDMD YRRSVSLINV IGQLLAVKLR DYYRYLNSNH YEVH