ID   HRCA_STRMU              Reviewed;         344 AA.
AC   O06940;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 3.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=SMU_80;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GS-5;
RX   PubMed=9282745; DOI=10.1046/j.1365-2958.1997.4671835.x;
RA   Jayaraman G.C., Penders J.E., Burne R.A.;
RT   "Transcriptional analysis of the Streptococcus mutans hrcA, grpE and dnaK
RT   genes and regulation of expression in response to heat shock and
RT   environmental acidification.";
RL   Mol. Microbiol. 25:329-341(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U78296; AAC45610.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN57865.1; -; Genomic_DNA.
DR   RefSeq; NP_720559.1; NC_004350.2.
DR   RefSeq; WP_002263415.1; NC_004350.2.
DR   AlphaFoldDB; O06940; -.
DR   SMR; O06940; -.
DR   STRING; 210007.SMU_80; -.
DR   PRIDE; O06940; -.
DR   EnsemblBacteria; AAN57865; AAN57865; SMU_80.
DR   KEGG; smu:SMU_80; -.
DR   PATRIC; fig|210007.7.peg.69; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; O06940; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182539"
FT   CONFLICT        37
FT                   /note="S -> R (in Ref. 1; AAC45610)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        57..69
FT                   /note="HTSSGRLPSQEGF -> TTPPAVVCPVKKAI (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        199
FT                   /note="L -> P (in Ref. 1; AAC45610)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        244
FT                   /note="N -> D (in Ref. 1; AAC45610)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   344 AA;  39231 MW;  AD3269E5693D77D4 CRC64;
     MITQRQKDIL NLIVELFTKT HEPIGSKTLQ NSIASSSATI RNDMAALEKL GLLEKAHTSS
     GRLPSQEGFR YFVEHSLNPD SLDEQDVYQV IKAFDFEAFR LGDLLQRASD VLANLTGYTA
     LILDVEPKKQ RLTTFDIVKL SNHDALAVLT LDEASPVTVQ FAIPKNFLDS DLMTVAKIAR
     ERFLNQTVLD IHYRLRTELP QIIQKYFPRT DNVLDLFDHI FNPIFQEEVF ISGKIKTLEF
     AGLNTYQFLE NLQSVALEIR QSLPEDELHR VQVADSKEKS LADLTVISQK FLIPYRGFGI
     LTVIGPVDLD YQRTISLINV ISRVLAVKLG DFYRYLNSNH YEVH