ID   HRCA_STRP2              Reviewed;         344 AA.
AC   Q04LY2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=SPD_0458;
OS   Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=373153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D39 / NCTC 7466;
RX   PubMed=17041037; DOI=10.1128/jb.01148-06;
RA   Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M.,
RA   Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.;
RT   "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus
RT   pneumoniae and comparison with that of unencapsulated laboratory strain
RT   R6.";
RL   J. Bacteriol. 189:38-51(2007).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000410; ABJ55034.1; -; Genomic_DNA.
DR   RefSeq; WP_000255770.1; NC_008533.2.
DR   AlphaFoldDB; Q04LY2; -.
DR   SMR; Q04LY2; -.
DR   STRING; 373153.SPD_0458; -.
DR   EnsemblBacteria; ABJ55034; ABJ55034; SPD_0458.
DR   GeneID; 60232518; -.
DR   KEGG; spd:SPD_0458; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   BioCyc; SPNE373153:G1G6V-500-MON; -.
DR   Proteomes; UP000001452; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010456"
SQ   SEQUENCE   344 AA;  39368 MW;  511AB7F8EC039612 CRC64;
     MVTERQQDIL NLIIDIFTKT HEPVGSKALQ ESINSSSATI RNDMAELEKQ GLLEKAHTSS
     GRMPSVAGFQ YYVKHSLDFD RLAENEVYEI VKAFDQEFFK LEDILQEAAN LLTDLSGCTV
     VALDVEPSRQ RLTAFDIVVL GQHTALAVFT LDESRTVTSQ FLIPRNFLQE DLLKLKSIIQ
     ERFLGHTVLD IHYKIRTEIP QIIQRYFTTT DNVIDLFEHI FKEMFNENIV MAGKVNLLNF
     ANLAAYQFFD QPQKVALEIR EGLREDQMQN VRVADGQESC LADLAVISSK FLIPYRGVGI
     LAIIGPVNLD YQQLINQINV VNRVLTMKLT DFYRYLSSNH YEVH