ID   HRCA_STRPD              Reviewed;         344 AA.
AC   Q1JFC6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=MGAS10270_Spy1568;
OS   Streptococcus pyogenes serotype M2 (strain MGAS10270).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=370552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS10270;
RX   PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA   Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R.,
RA   Musser J.M.;
RT   "Molecular genetic anatomy of inter- and intraserotype variation in the
RT   human bacterial pathogen group A Streptococcus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000260; ABF34633.1; -; Genomic_DNA.
DR   RefSeq; WP_011054942.1; NC_008022.1.
DR   AlphaFoldDB; Q1JFC6; -.
DR   SMR; Q1JFC6; -.
DR   EnsemblBacteria; ABF34633; ABF34633; MGAS10270_Spy1568.
DR   KEGG; sph:MGAS10270_Spy1568; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000002436; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010459"
SQ   SEQUENCE   344 AA;  39013 MW;  4F6891BE7A6CA3EE CRC64;
     MITQRQNDIL NLIVELFTQT HEPVGSKALQ RTIDSSSATI RNDMAKLEKL GLLEKAHTSS
     GRMPSPAGFK YFVEHSLRLD SIDEQDIYHV IKAFDFEAFK LEDMLQKASH ILSEMTGYTS
     VILDVEPARQ RLTGFDVVQL SNHDALAVMT LDESKPVTVQ FAIPRNFLTR DLIAFKAIVE
     ERLLDSSVID IHYKLRTEIP QIVQKYFVTT DNVLQLFDYV FSELFLETVF VAGKVNSLTY
     SDLSTYQFLD NEQQVAISLR QSLKEGEMAS VQVADSQEAA LADVSVLTHK FLIPYRGFGL
     LSLIGPIDMD YRRSVSLVNI IGKVLAAKLG DYYRYLNSNH YEVH