ID   HRCA_STRPN              Reviewed;         344 AA.
AC   Q9X4R2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2001, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=SP_0515;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Rx / CP1200;
RA   Kim S.-N., Kim S.-W., Choi I.-H., Rhee D.-K.;
RT   "hrcA in Streptococcus pneumoniae.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AF117740; AAD23452.1; -; Genomic_DNA.
DR   EMBL; AE005672; AAK74673.1; -; Genomic_DNA.
DR   PIR; H95059; H95059.
DR   RefSeq; WP_000255768.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q9X4R2; -.
DR   SMR; Q9X4R2; -.
DR   STRING; 170187.SP_0515; -.
DR   EnsemblBacteria; AAK74673; AAK74673; SP_0515.
DR   KEGG; spn:SP_0515; -.
DR   eggNOG; COG1420; Bacteria.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; Q9X4R2; -.
DR   BioCyc; SPNE170187:G1FZB-530-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182540"
FT   CONFLICT        236
FT                   /note="H -> N (in Ref. 1; AAD23452)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        272
FT                   /note="R -> A (in Ref. 1; AAD23452)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        318
FT                   /note="V -> I (in Ref. 1; AAD23452)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   344 AA;  39377 MW;  9A771B4024E3EFF5 CRC64;
     MVTERQQDIL NLIIDIFTKT HEPVGSKALQ ESINSSSATI RNDMAELEKQ GLLEKAHTSS
     GRMPSVAGFQ YYVKHSLDFD RLAENEVYEI VKAFDQEFFK LEDILQEAAN LLTDLSGCTV
     VALDVEPSRQ RLTAFDIVVL GQHTALAVFT LDESRTVTSQ FLIPRNFLQE DLLKLKSIIQ
     ERFLGHTVLD IHYKIRTEIP QIIQRYFTTT DNVIDLFEHI FKEMFNENIV MAGKVHLLNF
     ANLAAYQFFD QPQKVALEIR EGLREDQMQN VRVADGQESC LADLAVISSK FLIPYRGVGI
     LAIIGPVNLD YQQLINQVNV VNRVLTMKLT DFYRYLSSNH YEVH