ID   HRCA_STRPQ              Reviewed;         344 AA.
AC   P0DB67; Q8K623;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Heat-inducible transcription repressor hrcA;
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=SPs0333;
OS   Streptococcus pyogenes serotype M3 (strain SSI-1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=193567;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSI-1;
RX   PubMed=12799345; DOI=10.1101/gr.1096703;
RA   Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y.,
RA   Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H.,
RA   Hattori M., Hamada S.;
RT   "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-
RT   scale genomic rearrangement in invasive strains and new insights into phage
RT   evolution.";
RL   Genome Res. 13:1042-1055(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC63428.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000034; BAC63428.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011054942.1; NC_004606.1.
DR   AlphaFoldDB; P0DB67; -.
DR   SMR; P0DB67; -.
DR   KEGG; sps:SPs0333; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor hrcA"
FT                   /id="PRO_0000411371"
SQ   SEQUENCE   344 AA;  39013 MW;  4F6891BE7A6CA3EE CRC64;
     MITQRQNDIL NLIVELFTQT HEPVGSKALQ RTIDSSSATI RNDMAKLEKL GLLEKAHTSS
     GRMPSPAGFK YFVEHSLRLD SIDEQDIYHV IKAFDFEAFK LEDMLQKASH ILSEMTGYTS
     VILDVEPARQ RLTGFDVVQL SNHDALAVMT LDESKPVTVQ FAIPRNFLTR DLIAFKAIVE
     ERLLDSSVID IHYKLRTEIP QIVQKYFVTT DNVLQLFDYV FSELFLETVF VAGKVNSLTY
     SDLSTYQFLD NEQQVAISLR QSLKEGEMAS VQVADSQEAA LADVSVLTHK FLIPYRGFGL
     LSLIGPIDMD YRRSVSLVNI IGKVLAAKLG DYYRYLNSNH YEVH