ID   HRCA_STRSV              Reviewed;         344 AA.
AC   A3CQC4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=SSA_2009;
OS   Streptococcus sanguinis (strain SK36).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=388919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK36;
RX   PubMed=17277061; DOI=10.1128/jb.01808-06;
RA   Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA   Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA   Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT   "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL   J. Bacteriol. 189:3166-3175(2007).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000387; ABN45379.1; -; Genomic_DNA.
DR   RefSeq; WP_011837494.1; NC_009009.1.
DR   RefSeq; YP_001035929.1; NC_009009.1.
DR   AlphaFoldDB; A3CQC4; -.
DR   SMR; A3CQC4; -.
DR   STRING; 388919.SSA_2009; -.
DR   EnsemblBacteria; ABN45379; ABN45379; SSA_2009.
DR   KEGG; ssa:SSA_2009; -.
DR   PATRIC; fig|388919.9.peg.1904; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000002148; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010463"
SQ   SEQUENCE   344 AA;  39332 MW;  3173724369100801 CRC64;
     MVTERQNEIL NLIIDIFTKT HEPVGSKALQ DSINSSSATI RNDMAALEKQ GLLEKAHTSS
     GRKPSVAGFQ YFVKHSLSFD RLAENELYEV IKAFDHEFFN LEDILQQAAD LLTKLSGCTV
     VALDVEPSRQ RLTAFDIVVL SQHTALAVFT LDESNTITSQ FMIPRNFLKE DLDRLKGLVR
     ERFLGQTVLD IHYKIRTEIP QIIQRYFTTT DNVIQLFEHI FGDIFKENVI LSGKVQLLEF
     SDLTAYQFFD DPQKVAFEIR DSLAEDQMQS VRVADSRESC LADLTLISSK FLIPYRGFGV
     LAVVGPVNLD YQRLVSQMNV VNRVLTMKLT DFYRYLSSNH YEVH