ID   HRCA_STRT2              Reviewed;         360 AA.
AC   Q5M6D3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=stu0118;
OS   Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=264199;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-250 / LMG 18311;
RX   PubMed=15543133; DOI=10.1038/nbt1034;
RA   Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D.,
RA   Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M.,
RA   Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D.,
RA   Hancy F., Burteau S., Boutry M., Delcour J., Goffeau A., Hols P.;
RT   "Complete sequence and comparative genome analysis of the dairy bacterium
RT   Streptococcus thermophilus.";
RL   Nat. Biotechnol. 22:1554-1558(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000023; AAV59843.1; -; Genomic_DNA.
DR   RefSeq; WP_011225328.1; NC_006448.1.
DR   AlphaFoldDB; Q5M6D3; -.
DR   SMR; Q5M6D3; -.
DR   STRING; 264199.stu0118; -.
DR   DNASU; 3164703; -.
DR   EnsemblBacteria; AAV59843; AAV59843; stu0118.
DR   GeneID; 66898043; -.
DR   KEGG; stl:stu0118; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001170; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..360
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010465"
SQ   SEQUENCE   360 AA;  41055 MW;  635EA2327B885F0D CRC64;
     MITQRQNAIL NLIVEMFTRT HEPVCSKALQ DSIDSSSATI RNDMAKLEKM GYLEKAHISS
     GRMPSRAGFQ YFVANSLNLD TIDEQDVYQV VKAFDFEAFK LEDILDAAAK LLAEMTGCTA
     VIQDVEPTKQ RLTGFEIVQL SNHDALAVLT LDESKPVTVQ FAIPKNFLSS DLEIFHKLVQ
     GRFLGNTVLD IHYRLRTETP QIVQKYFKIT DNVLDLFDYI FSHLFKELIF IEGKVASLAY
     ADLKTYQFLD NPQHVALALR SAISDDEVTK ISVAESTEEA LENVTVMSHK FLIPYRGTAL
     MHVIGPIEMD YRRMVSLVNV ISRVLVMKLT DYYRYLNSNH YEVFLSRNVL KNIERGECLD